Interleukin-27 induces the endothelial differentiation in Sca-1+ cardiac resident stem cells. Issue 2 (October 2015)

• Record Type: Journal Article
• Authors: Tanaka, Tomohiro; Obana, Masanori; Mohri, Tomomi; Ebara, Masaki; Otani, Yuta; Maeda, Makiko; Fujio, Yasushi
• Is Part Of: Cytokine. Volume 75:Issue 2(2015)
• Page Start: 365
• Page End: 372
• Publication Date: 2015-10
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.06.009
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">IL-27Rα was expressed in cardiac Sca-1+ cells.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">The transcript expression of IL-27 was elevated in hearts in cardiac injury models.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">STAT3/Pim-1 axis was activated by IL-27 in cardiac Sca-1+ cells.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">IL-27 induces the endothelial differentiation in Sca-1+ cells through STAT3/Pim-1.</p> </list-item> </list> </p> </sec> </abstract>