Beyond conventional chemotherapy: Emerging molecular targeted and immunotherapy strategies in urothelial carcinoma. Issue 8 (September 2015)

• Record Type: Journal Article
• Authors: Ikeda, Sadakatsu; Hansel, Donna E.; Kurzrock, Razelle
• Is Part Of: Cancer treatment reviews. Volume 41:Issue 8(2015)
• Page Start: 699
• Page End: 706
• Publication Date: 2015-09
• Subjects: Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2015.06.004
• Languages: English
• ISSNs: 0305-7372

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st005">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0005">Conventional chemotherapy for urothelial carcinoma has reached the plateau.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0010">No molecular targeted therapy is available in urothelial carcinoma.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0015">Molecular profiling revealed actionable genetic alterations, such as PIK3CA, FGFR3, and HER2.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0020">Immune checkpoint inhibitors demonstrated early promising results.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0025">Novel clinical trials incorporating molecular and immune biomarkers are warranted.</p> </list-item> </list> </p> </sec> </abstract>