Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity. Issue 18 (15th September 2015)

• Record Type: Journal Article
• Authors: Congiu, Cenzo; Onnis, Valentina; Deplano, Alessandro; Balboni, Gianfranco; Dedeoglu, Nurcan; Supuran, Claudiu T.
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 25:Issue 18(2015)
• Page Start: 3850
• Page End: 3853
• Publication Date: 2015-09-15
• Subjects: Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2015.07.060
• Languages: English
• ISSNs: 0960-894X

Abstract

<abstract xml:lang="en" abstract-type="graphical" id="ab005"> <title id="st005">Graphical abstract</title> <sec> <p id="sp0005"> <italic>K</italic> _I (hCA I) = 7.5–9490 nM; <italic>K</italic>_I (hCA II) = 0.75–721 nM; <italic>K</italic>_I (hCA IX) = 8.7–517 nM; <italic>K</italic>_I (hCA XII) = 17.0–179 nM. <fig id="f0015" position="anchor"><graphic position="anchor" xlink:href="ark:/27927/pgj2msgqnvp" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></fig></p> </sec> </abstract>