Elevated baseline plasma IL-8 levels are an independent predictor of long-term all-cause mortality in patients with acute coronary syndrome. Issue 2 (October 2015)

• Record Type: Journal Article
• Authors: Cavusoglu, Erdal; Marmur, Jonathan D.; Yanamadala, Sunitha; Chopra, Vineet; Hegde, Sudhanva; Nazli, Anila; Singh, Kamal Preet; Zhang, Ming; Eng, Calvin
• Is Part Of: Atherosclerosis. Volume 242:Issue 2(2015)
• Page Start: 589
• Page End: 594
• Publication Date: 2015-10
• Subjects: Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2015.08.022
• Languages: English
• ISSNs: 0021-9150

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Objectives</title> <p id="abspara0010">To investigate the long-term prognostic significance of baseline plasma IL-8 levels in a group of well-characterized male patients presenting with acute coronary syndrome.</p> </sec> <sec> <title id="sectitle0020">Background</title> <p id="abspara0015">IL-8 is a cytokine that has been implicated in the pathogenesis of atherosclerosis and acute coronary syndrome. Elevated plasma levels have been reported in patients with acute coronary syndrome.</p> </sec> <sec> <title id="sectitle0025">Methods</title> <p id="abspara0020">Baseline plasma IL-8 levels were measured in 180 male patients with acute coronary syndrome who were referred for coronary angiography and followed prospectively for the development of all-cause mortality for 5 years.</p> </sec> <sec> <title id="sectitle0030">Results</title> <p id="abspara0025">In a multivariate model that included a wide variety of baseline clinical, laboratory and angiographic parameters in the selection process, baseline plasma IL-8 levels (analyzed as a continuous variable) emerged as a significant predictor of all-cause mortality at 5 years (HR, 1.43; 95% CI, 1.08–1.88; p = 0.0123). Furthermore, in 3 additional multivariate models that also included in the selection process a number of contemporary biomarkers with established prognostic efficacy in ACS (i.e., NT-proBNP, hs-CRP, hemoglobin and RDW), IL-8 remained an independent predictor of all-cause mortality at 5 years.</p> </sec> <sec> <title id="sectitle0035">Conclusion</title> <p id="abspara0030">Elevated baseline plasma levels of IL-8 are associated with an increased risk of long-term all-cause mortality in patients with acute coronary syndrome. Furthermore, this association is independent of a variety of clinical, laboratory and angiographic variables, including contemporary biomarkers with established prognostic efficacy in acute coronary syndrome.</p> </sec> </abstract>