Relationship between Cnm‐positive Streptococcus mutans and cerebral microbleeds in humans. (1st September 2015)

• Record Type: Journal Article
• Authors: Miyatani, F; Kuriyama, N; Watanabe, I; Nomura, R; Nakano, K; Matsui, D; Ozaki, E; Koyama, T; Nishigaki, M; Yamamoto, T; Mizuno, T; Tamura, A; Akazawa, K; Takada, A; Takeda, K; Yamada, K; Nakagawa, M; Ihara, M; Kanamura, N; Friedland, RP; Watanabe, Y
• Is Part Of: Oral diseases. Volume 21:Number 7(2015:Oct.)
• Page Start: 886
• Page End: 893
• Publication Date: 2015-09-01
• Subjects: Mouth -- Diseases -- Research -- Periodicals; 617.522
• DOI: 10.1111/odi.12360
• Languages: English
• ISSNs: 1354-523X

Abstract

<abstract abstract-type="main" id="odi12360-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="odi12360-sec-0001" sec-type="section"> <title>Objective</title> <p>Cerebral hemorrhage has been shown to occur in animals experimentally infected with Streptococcus mutans carrying the collagen‐binding <italic>Cnm</italic> gene. However, the relationship between cerebral microbleeds and oral hygiene, with a focus on <italic>Cnm</italic> gene‐positive <italic>S. mutans</italic> infection, remains unclear.</p> </sec> <sec id="odi12360-sec-0002" sec-type="section"> <title>Material and Methods</title> <p>One hundred and thirty‐nine subjects participated. The presence or absence of <italic>Cnm</italic>‐positive <italic>S. mutans</italic> and its collagen‐binding activity were investigated using saliva samples, and relationship with cerebral microbleeds detected on MRI investigated, including clinical information and oral parameters.</p> </sec> <sec id="odi12360-sec-0003" sec-type="section"> <title>Results</title> <p>Fifty‐one subjects were identified as <italic>Cnm</italic>‐positive <italic>S. mutans</italic> carriers (36.7%), with cerebral microbleeds being detected in 43 (30.9%). A significantly larger number of subjects carried <italic>Cnm</italic>‐positive <italic>S. mutans</italic> in the cerebral microbleeds (+) group. <italic>S. mutans</italic> with Cnm collagen‐binding ability was detected in 39 (28.1%) of all subjects, and the adjusted odds ratio for cerebral microbleeds in the Cnm‐positive group was 14.4. Regarding the presence of cerebral microbleeds, no significant differences were noted in the number of remaining teeth, dental caries, or in classic arteriosclerosis risk factors.</p> </sec> <sec id="odi12360-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The occurrence of cerebral microbleeds was higher in subjects carrying <italic>Cnm</italic>‐positive <italic>S. mutans</italic>, indicating that the presence of <italic>Cnm</italic>‐positive <italic>S. mutans</italic> increases cerebral microbleeds, and is an independent risk for the development of cerebrovascular disorders.</p> </sec> </abstract>