Comparison of fitting methods and b‐value sampling strategies for intravoxel incoherent motion in breast cancer. Issue 4 (9th October 2014)

• Record Type: Journal Article
• Authors: Cho, Gene Young; Moy, Linda; Zhang, Jeff L.; Baete, Steven; Lattanzi, Riccardo; Moccaldi, Melanie; Babb, James S.; Kim, Sungheon; Sodickson, Daniel K.; Sigmund, Eric E.
• Is Part Of: Magnetic resonance in medicine. Volume 74:Issue 4(2015:Oct.)
• Page Start: 1077
• Page End: 1085
• Publication Date: 2014-10-09
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.25484
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm25484-sec-0001" sec-type="section"> <title>Purpose</title> <p>To compare fitting methods and sampling strategies, including the implementation of an optimized b‐value selection for improved estimation of intravoxel incoherent motion (IVIM) parameters in breast cancer.</p> </sec> <sec id="mrm25484-sec-0002" sec-type="section"> <title>Methods</title> <p>Fourteen patients (age, 48.4 ± 14.27 years) with cancerous lesions underwent 3 Tesla breast MRI examination for a HIPAA‐compliant, institutional review board approved diffusion MR study. IVIM biomarkers were calculated using "free" versus "segmented" fitting for conventional or optimized (repetitions of key b‐values) b‐value selection. Monte Carlo simulations were performed over a range of IVIM parameters to evaluate methods of analysis. Relative bias values, relative error, and coefficients of variation (CV) were obtained for assessment of methods. Statistical paired t‐tests were used for comparison of experimental mean values and errors from each fitting and sampling method.</p> </sec> <sec id="mrm25484-sec-0003" sec-type="section"> <title>Results</title> <p>Comparison of the different analysis/sampling methods in simulations and experiments showed that the "segmented" analysis and the optimized method have higher precision and accuracy, in general, compared with "free" fitting of conventional sampling when considering all parameters. Regarding relative bias, IVIM parameters f<sub>p</sub> and D<sub>t</sub> differed significantly between "segmented" and "free" fitting methods.</p> </sec> <sec id="mrm25484-sec-0004" sec-type="section"> <title>Conclusion</title> <p>IVIM analysis may improve using optimized selection and "segmented" analysis, potentially enabling better differentiation of breast cancer subtypes and monitoring of treatment. Magn Reson Med 74:1077–1085, 2015. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>