Mediator Variables in Headache Research: Methodological Critique and Exemplar Using Self‐Efficacy as a Mediator of the Relationship Between Headache Severity and Disability. Issue 8 (6th August 2015)

• Record Type: Journal Article
• Authors: Peck, Kelly R.; Smitherman, Todd A.
• Is Part Of: Headache. Volume 55:Issue 8(2015)
• Page Start: 1102
• Page End: 1111
• Publication Date: 2015-08-06
• Subjects: Headache -- Periodicals; Headache -- Periodicals; 616.8491
• DOI: 10.1111/head.12633
• Languages: English
• ISSNs: 0017-8748

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="head12633-sec-0001" sec-type="section"> <title>Background</title> <p>Despite advances in headache medicine, there remains little research on process‐related variables that mediate relations between headache and outcomes, as well as limited dissemination of optimal statistical methodology for conducting mediation analyses. The present paper thus aims to promote and demonstrate a contemporary approach to mediation analysis as applied to headache.</p> </sec> <sec id="head12633-sec-0002" sec-type="section"> <title>Methods</title> <p>An overview of a contemporary path‐analytic approach to mediation analysis is presented, with an empirical exemplar for illustrative purposes. In the exemplar, headache management self‐efficacy (HMSE) was proposed as a mediator between headache severity and disability. The sample included 907 young adults (M age = 19.03 [SD = 2.26]; 70.8% female) with primary headache. Direct and indirect effects of headache severity on headache disability through HMSE were assessed using the espoused methods.</p> </sec> <sec id="head12633-sec-0003" sec-type="section"> <title>Results</title> <p>Pain severity was positively associated with headache disability (<italic>β</italic> = 2.91, 95% confidence interval [CI; 2.62, 3.19]) and negatively associated with HMSE (<italic>β</italic> = −3.50, 95% CI [−4.24, −2.76]); HMSE was negatively associated with headache disability (<italic>β</italic> = 0.07, 95% CI [−0.09, −0.04]). A positive indirect effect of pain severity on disability through HMSE was identified (point estimate = 0.24, 95% CI [0.14, 0.34]); thus, self‐efficacy mediated the association between pain severity and disability. The proposed mediation model accounted for 38% of total variance in disability (<italic>P</italic> < .001).</p> </sec> <sec id="head12633-sec-0004" sec-type="section"> <title>Conclusions</title> <p>There is a need for theory‐driven and statistically rigorous mediation analyses within the headache literature. In one exemplar application, self‐efficacy partially accounted for the disability resulting from headache. We advocate for increased attention to intervening variables in headache via dissemination of contemporary mediation analyses.</p> </sec> </abstract>