Challenging the two concepts in determining the appropriate pre‐discharge N‐terminal pro‐brain natriuretic peptide treatment target in acute decompensated heart failure patients: absolute or relative discharge levels?. (29th July 2015)

• Record Type: Journal Article
• Authors: Stienen, Susan; Salah, Khibar; Eurlings, Luc W.M.; Bettencourt, Paulo; Pimenta, Joana M.; Metra, Marco; Bayes‐Genis, Antoni; Verdiani, Valerio; Bettari, Luca; Lazzarini, Valentina; Tijssen, Jan P.; Pinto, Yigal M.; Kok, Wouter E.M.
• Is Part Of: European journal of heart failure. Volume 17:Number 9(2015)
• Page Start: 936
• Page End: 944
• Publication Date: 2015-07-29
• Subjects: Heart failure -- Periodicals; Heart Failure -- Periodicals; Insuffisance cardiaque -- Périodiques; Heart failure; Periodicals; 616.129005
• DOI: 10.1002/ejhf.320
• Languages: English
• ISSNs: 1388-9842

Abstract

<abstract abstract-type="main" id="ejhf320-abs-0001"> <title>Abstract</title> <sec id="ejhf320-sec-0001" sec-type="section"> <title>Aims</title> <p id="ejhf320-para-0001">NT‐proBNP is a strong predictor for readmissions and mortality in acute decompensated heart failure (ADHF) patients. We assessed whether absolute or relative NT‐proBNP levels should be used as pre discharge treatment target.</p> </sec> <sec id="ejhf320-sec-0002" sec-type="section"> <title>Methods and results</title> <p id="ejhf320-para-0002">Our study population was assembled from seven ADHF cohorts. We defined absolute (<1500, <3000, <5000, and <15 000 ng/L) and relative NT‐proBNP targets (>30, >50, and >70%). Population attributable risk fraction (PARF) is the proportion of all‐cause 6‐month mortality in the population that would be reduced if all patients attain the NT‐proBNP target. PARF was determined for each target as well as the percentage of patients attaining the NT‐proBNP target. Attainability was investigated by logistic regression analysis. A total of 1266 patients [age 74 (64–80), 60% male] was studied. For every absolute NT‐proBNP level, a corresponding percentage reduction was found that resulted in similar PARFs. The highest PARF (∼60–70%) was observed for <1500 or >70%, but attainability was low (27% and 22%, respectively). The strongest predictor for not attaining these targets was admission NT‐proBNP. In admission NT‐proBNP tertiles, PARFs were significantly different for absolute, but not for relative targets.</p> </sec> <sec id="ejhf320-sec-0003" sec-type="section"> <title>Conclusion</title> <p id="ejhf320-para-0003">In an ADHF population, pre‐discharge absolute or relative NT‐proBNP targets may both be useful as they have similar effects on PARF. However, depending on admission NT‐proBNP, absolute targets show varying PARFs, while PARFs for relative targets were similar. A relative target is predicted to reduce mortality consistently across the whole spectrum of ADHF patients, while this is not the case using a single absolute target.</p> </sec> </abstract>