Blood group AB is protective factor for gestational diabetes mellitus: a prospective population‐based study in Tianjin, China. Issue 6 (11th May 2015)

• Record Type: Journal Article
• Authors: Zhang, Cuiping; Li, Yi; Wang, Leishen; Sun, Shurong; Liu, Gongshu; Leng, Junhong; Guo, Jia; Lv, Li; Li, Weidong; Zhang, Cuilin; Hu, Gang; Yu, Zhijie; Yang, Xilin
• Is Part Of: Diabetes/metabolism research and reviews. Volume 31:Issue 6(2015:Sep.)
• Page Start: 627
• Page End: 637
• Publication Date: 2015-05-11
• Subjects: Diabetes -- Periodicals; Metabolism -- Periodicals; 616.642
• DOI: 10.1002/dmrr.2650
• Languages: English
• ISSNs: 1520-7552

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="dmrr2650-sec-0001" sec-type="section"> <title>Background</title> <p>The ABO blood types are associated with cancers, cardiovascular diseases and type 2 diabetes mellitus but whether they are also associated with gestational diabetes mellitus (GDM) is unknown. We examined the relationship between the ABO blood types and the risk of GDM in a prospective population‐based Chinese cohort.</p> </sec> <sec id="dmrr2650-sec-0002" sec-type="section"> <title>Methods</title> <p>From 2010 to 2012, we recruited 14 198 pregnant women within the first 12 weeks of gestation in Tianjin, China. All women had a glucose challenge test (GCT) at 24–28 gestational weeks, followed by a 75‐g 2‐h oral glucose tolerance test if the results from GCT were ≥7.8 mmol/L. GDM was diagnosed based on the glucose cut‐points of the International Association of Diabetes and Pregnancy Study Group criteria. Logistic regression was used to obtain odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for traditional risk factors. Stratified analysis was performed by family history of diabetes (yes <italic>versus</italic> no). Sensitivity analyses were also performed by using the World Health Organization (WHO) criteria for GDM.</p> </sec> <sec id="dmrr2650-sec-0003" sec-type="section"> <title>Results</title> <p>Women with blood groups A, B or O (i.e. non‐AB) were associated with increased risk of GDM as compared with those with blood group AB (adjusted OR: 1.44, 95% CI: 1.13–1.83). Sensitivity analyses showed that the result was consistent using WHO criteria. The adjusted OR of blood group non‐AB <italic>versus</italic> AB for GDM was enhanced among women with a family history of diabetes (2.69, 1.21–5.96) and attenuated among those without (1.33, 1.03–1.71).</p> </sec> <sec id="dmrr2650-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Blood group AB was a protective factor against GDM in pregnant Chinese women. Copyright © 2015 John Wiley & Sons, Ltd.</p> </sec> </abstract>