Cover Picture: Direct Construction of the 9H‐Pyrrolo[1, 2‐a]azepin‐9‐amine Skeleton via [4+3] Annulation of Alkyl 2‐Aroyl‐1‐chlorocyclo‐ propanecarboxylates (Adv. Synth. Catal. 13/2015). Issue 13 (15th September 2015)

• Record Type: Journal Article
• Authors: Hu, Junhao; Liu, Yang; Gong, Yuefa
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 13(2015)
• Page Start: 2733
• Page End: 2733
• Publication Date: 2015-09-15
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500739
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>The front cover picture</bold>, provided by Yuefa Gong and co‐workers, illustrates a highly diastereoselective approach for direct synthesis of the important 9<italic>H</italic>‐pyrrolo[1, 2‐<italic>a</italic>]azepin‐9‐amines. This transition metal‐free [4+3] annulation reaction between donor‐acceptor reagents derived from 1<italic>H</italic>‐pyrrole‐2‐carbaldehydes and alkyl 2‐aroyl‐1‐chlorocyclopropanecarboxylates proceeded quickly under mild basic conditions, affording azepin‐9‐amine derivatives in moderate to high yields with high diastereoselectivities. Details can be found in the communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">pages 2781–2787 (J. Hu, Y. Liu, Y. Gong, Adv. Synth. Catal. 2015, 357, 2781–2787; DOI: 10.1002/adsc.201500376</ext-link>).<graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj2n0t625z" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>