Aryl λ3‐Iodane‐Mediated 6‐exo‐trig Cyclization to Synthesize Highly Substituted Chiral Morpholines. Issue 13 (11th September 2015)

• Record Type: Journal Article
• Authors: Kishore Vandavasi, Jaya; Hu, Wan‐Ping; Chandru Senadi, Gopal; Chen, Hui‐Ting; Chen, Hsing‐Yin; Hsieh, Kuang‐Chan; Wang, Jeh‐Jeng
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 13(2015)
• Page Start: 2788
• Page End: 2794
• Publication Date: 2015-09-11
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500177
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A mild and efficient transition metal‐free approach has been developed for the synthesis of highly substituted chiral morpholines from alkenols by amino acid‐derived iodine(III) reagents <italic>via</italic> a 6‐<italic>exo</italic>‐<italic>trig</italic> cyclization. The key features of this work include the formation of three chiral centers with a high diastereomeric ratio, broad functional group compatibility, and atom/time economic methodology.</p> <p> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj2n0t65t0" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </p> </abstract>