Synthesis of Tetrasubstituted Pyrroles from Homopropargylic Amines via a Sonogashira Coupling/Intramolecular Hydroamination/Oxidation Sequence. Issue 13 (10th September 2015)

• Record Type: Journal Article
• Authors: Wang, Chan; Huang, Kaimeng; Wang, Junying; Wang, Hongkai; Liu, Lingyan; Chang, Weixing; Li, Jing
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 13(2015)
• Page Start: 2795
• Page End: 2802
• Publication Date: 2015-09-10
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500350
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A one‐pot reaction of homopropargylic amines and aryl iodides was developed in the presence of a palladium (Pd) catalyst and generated a series of tetrasubstituted pyrrole derivatives in good to high yields. This process involved a Sonogashira, intramolecular hydroamination, cyclization and oxidation sequence of reactions.</p> <p> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj2n0t4ngr" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </p> </abstract>