Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles. (21st July 2015)

• Record Type: Journal Article
• Authors: Chiappini, Ciro; Campagnolo, Paola; Almeida, Carina S.; Abbassi‐Ghadi, Nima; Chow, Lesley W.; Hanna, George B.; Stevens, Molly M.
• Is Part Of: Advanced materials. Volume 27:Number 35(2015)
• Page Start: 5147
• Page End: 5152
• Publication Date: 2015-07-21
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201501304
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201501304-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Porous silicon nanoneedles</bold> can map Cathepsin B activity across normal and tumor human esophageal mucosa. Assembling a peptide‐based Cathepsin B cleavable sensor over a large array of nano­needles allows the discrimination of cancer cells from healthy ones in mixed culture. The same sensor applied to tissue can map Cathepsin B activity with high resolution across the tumor margin area of esophageal adenocarcinoma. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj2n0rvqzr" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>