Ankle‐brachial index and inter‐artery blood pressure differences as predictors of cognitive function in overweight and obese older adults with diabetes: results from the Action for Health in Diabetes movement and memory study. (26th December 2014)

• Record Type: Journal Article
• Authors: Espeland, Mark A.; Beavers, Kristen M.; Gibbs, Bethany Barone; Johnson, Karen C.; Hughes, Timothy M.; Baker, Laura D.; Jakicic, John; Korytkowski, Mary; Miller, Marsha; Bray, George A.
• Is Part Of: International journal of geriatric psychiatry. Volume 30:Number 10(2015:Oct.)
• Page Start: 999
• Page End: 1007
• Publication Date: 2014-12-26
• Subjects: Geriatric psychiatry -- Periodicals; Geriatric Psychiatry -- Periodicals; 618.97689
• DOI: 10.1002/gps.4253
• Languages: English
• ISSNs: 0885-6230

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="gps4253-sec-0001" sec-type="section"> <title>Objective</title> <p>Ankle‐brachial index (ABI) and interartery systolic blood pressure differences, as markers of vascular disease, are plausible risk factors for deficits in cognitive function among overweight and obese adults with type 2 diabetes.</p> </sec> <sec id="gps4253-sec-0002" sec-type="section"> <title>Methods</title> <p>The ABI and maximum interartery differences (MIAD) in systolic blood pressures were assessed annually for five years among 479 participants assigned to the control condition in a randomized clinical trial of a behavioral weight loss intervention. A battery of standardized cognitive function tests was administered 4 to 5 years later. Analyses of covariance were used to assess relationships that ABI, MIAD, and progression of ABI and MIAD had with cognitive function.</p> </sec> <sec id="gps4253-sec-0003" sec-type="section"> <title>Results</title> <p>There was a curvilinear relationship between ABI and a composite index of cognitive function (<italic>p</italic> = 0.03), with lower ABI being associated with poorer function. In graded fashions, both greater MIAD and increases in MIAD over time also had modest relationships with poorer verbal memory (both <italic>p</italic> ≤ 0.05), processing speed (both <italic>p</italic> ≤ 0.05), and composite cognitive function (both <italic>p</italic> < 0.04). These relationships were independent of each other and remained evident after extensive covariate adjustment.</p> </sec> <sec id="gps4253-sec-0004" sec-type="section"> <title>Conclusions</title> <p>In overweight and obese adults with type 2 diabetes, lower ABI and larger interartery systolic blood pressure differences have modest, independent, graded relationships with poorer cognitive function 4–5 years later. Copyright © 2014 John Wiley & Sons, Ltd.</p> </sec> </abstract>