Aminolevulinic acid dendrimers in photodynamic treatment of cancer and atheromatous disease1. Issue 9 (26th September 2015)

• Record Type: Journal Article
• Authors: Rodriguez, L.; Vallecorsa, P.; Battah, S.; Di Venosa, G.; Calvo, G.; Mamone, L.; Sáenz, D.; Gonzalez, M. C.; Batlle, A.; MacRobert, A. J.; Casas, A.
• Is Part Of: Photochemical & photobiological sciences. Volume 14:Issue 9(2015:Sep.)
• Page Start: 1617
• Page End: 1627
• Publication Date: 2015-09-26
• Subjects: Photochemistry -- Periodicals; Photobiology -- Periodicals; 541.35
• DOI: 10.1039/c5pp00126a
• Languages: English
• ISSNs: 1474-905X

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgj2gzsf8pz" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />ALA dendrimers are taken up by caveolae-mediated endocytosis in macrophages. Intracellular ALA release gives rise to PpIX synthesis and subsequent photosensitization of key cells in atheromas and tumour diseases.</p> </abstract>