Association study between reward dependence and a functional BDNF polymorphism in adult women offspring of alcohol-dependent probands. (October 2015)

• Record Type: Journal Article
• Authors: Benzerouk, Farid; Gierski, Fabien; Raucher-Chéné, Delphine; Ramoz, Nicolas; Gorwood, Philip; Kaladjian, Arthur; Limosin, Frédéric
• Is Part Of: Psychiatric genetics. Volume 25:Number 5(2015:Oct.)
• Publication Date: 2015-10
• Subjects: Mental illness -- Genetic aspects -- Periodicals; Periodicals; 616.89042
• DOI: 10.1097/YPG.0000000000000099
• Languages: English
• ISSNs: 0955-8829

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p>Thirty-five healthy adult women offspring of alcohol-dependent probands (AWOA) were compared with 63 healthy controls to test whether personality dimensions on the Temperament and Character Inventory questionnaire were associated with the brain-derived neurotrophic factor Val66Met polymorphism in offspring. We found a significantly lower reward dependence score in AWOA compared with the controls. The brain-derived neurotrophic factor Val66Met polymorphism may be involved in this difference as the lower reward dependence score was found only in AWOA carrying the Val allele.</p> </sec> </abstract>