Impact of ESR1 Gene Polymorphisms on Migraine Susceptibility. Issue 35 (September 2015)

• Record Type: Journal Article
• Authors: Li, Li; Liu, Ruozhuo; Dong, Zhao; Wang, Xiaolin; Yu, Shengyuan; Peng, Qi.
• Is Part Of: Medicine. Volume 94:Issue 35(2015)
• Publication Date: 2015-09
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000000976
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>An increasing number of studies have explored genetic associations between the functionally important polymorphisms in estrogen receptor 1 (<italic>ESR1</italic>) gene and migraine susceptibility. The previously reported associations have nevertheless been inconsistent.</p> <p>The present work incorporating the published data derived from 8 publications was performed to assess the impact of these polymorphisms on incident migraine. Strength of the genetic risk was estimated by means of an odds ratio along with the 95% confidence interval (OR and 95% CI).</p> <p>From the results, we found individuals who harbored the 325-GG genotype, compared with those harboring the CC genotype or CG and CC combined genotypes, had almost 50% greater risk of migraine. The same genetic models showed notable associations in subgroups of Caucasians and migraine with aura (MA). For 594G>A, a moderately increased risk of migraine was seen under AG versus GG. The AA + AG versus GG model, however, showed a borderline association with migraine. Subgroup analyses according to ethnicity and subtype of migraine provided statistical evidence of significantly increased risk of migraine in Caucasians and of a marginal association with MA, respectively. Both 325C>G and 594G>A polymorphisms showed no major effects either in males or in females.</p> <p>Based on the statistical data, we conclude some of the <italic>ESR1</italic> gene polymorphisms may have major contributions to the pathogenesis of migraine in Caucasian populations.</p> </sec> </abstract>