Cohort Study of Carbon Black Exposure and Risk of Malignant and Nonmalignant Respiratory Disease Mortality in the US Carbon Black Industry. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Dell, Linda D.; Gallagher, Alexa E.; Crawford, Lori; Jones, Rachael M.; Mundt, Kenneth A.
• Is Part Of: Journal of occupational and environmental medicine. Volume 57:Issue 9(2015)
• Publication Date: 2015-09
• Subjects: Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational Medicine -- Periodicals; Environmental Medicine -- Periodicals; Environmental health; Medicine, Industrial; Periodicals; Electronic journals; 616.9803
• DOI: 10.1097/JOM.0000000000000511
• Languages: English
• ISSNs: 1076-2752

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objective:</title> <p>To evaluate lung cancer and respiratory disease mortality associations with cumulative inhalable carbon black exposure among 6634 US carbon black workers.</p> </sec> <sec> <title>Methods:</title> <p>This analysis was performed using standardized mortality ratio (SMRs) and Cox regression analyses.</p> </sec> <sec> <title>Results:</title> <p>Lung cancer mortality was decreased overall (SMR = 0.77; 95% confidence interval [CI], 0.67 to 0.89) but less so among hourly male workers (SMR = 0.87; 95% CI, 0.71 to 1.05). No exposure–response association was observed with time-dependent cumulative inhalable carbon black: hazard ratio [HR] = 1.0 (95% CI, 0.6 to 1.6) for 20 to less than 50 mg/m³·yr); HR = 1.3 (95% CI, 0.8 to 2.1) for 50 to less than 100 mg/m³·yr; and HR = 1.4 (95% CI, 0.9 to 2.1) for 100 mg/m³·yr or more compared with referent (&lt;20 mg/m³·yr). No consistent associations were observed between cumulative inhalable carbon black exposure and respiratory disease mortality.</p> </sec> <sec> <title>Conclusion:</title> <p>Quantitative carbon black exposure estimates were not related to lung cancer or nonmalignant respiratory disease mortality.</p> </sec> </abstract>