Association of PCK1 with Body Mass Index and Other Metabolic Features in Patients With Psychotropic Treatments. Issue 5 (October 2015)

• Record Type: Journal Article
• Authors: Saigi-Morgui, Núria; Vandenberghe, Frederik; Delacrétaz, Aurélie; Quteineh, Lina; Choong, Eva; Gholamrezaee, Mehdi; Magistretti, Pierre; Aubry, Jean-Michel; von Gunten, MPhil, Armin; Preisig, Martin; Castelao, Enrique; Vollenweider, Peter; Waeber, Gerard; Kutalik, Zoltán; Conus, Philippe; Eap, Chin B.
• Is Part Of: Journal of clinical psychopharmacology. Volume 35:Issue 5(2015)
• Publication Date: 2015-10
• Subjects: Psychopharmacology -- Periodicals; Psychopharmacology -- Periodicals; Psychopharmacologie -- Périodiques; Psychopharmacology; Periodicals; 615.78
• DOI: 10.1097/JCP.0000000000000388
• Languages: English
• ISSNs: 0271-0749

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>Weight gain is a major health problem among psychiatric populations. It implicates several receptors and hormones involved in energy balance and metabolism. Phosphoenolpyruvate carboxykinase 1 is a rate-controlling enzyme involved in gluconeogenesis, glyceroneogenesis and cataplerosis and has been related to obesity and diabetes phenotypes in animals and humans. The aim of this study was to investigate the association of <italic>phosphoenolpyruvate carboxykinase 1</italic> polymorphisms with metabolic traits in psychiatric patients treated with psychotropic drugs inducing weight gain and in general population samples. One polymorphism (<italic>rs11552145G > A</italic>) significantly associated with body mass index in the psychiatric discovery sample (n = 478) was replicated in 2 other psychiatric samples (n<sub>1</sub> = 168, n<sub>2</sub> = 188), with <italic>AA</italic>-genotype carriers having lower body mass index as compared to <italic>G-allele</italic> carriers. Stronger associations were found among women younger than 45 years carrying <italic>AA</italic>-genotype as compared to <italic>G-allele</italic> carriers (−2.25 kg/m<sup>2</sup>, n = 151, <italic>P</italic> = 0.009) and in the discovery sample (−2.20 kg/m<sup>2</sup>, n = 423, <italic>P</italic> = 0.0004). In the discovery sample for which metabolic parameters were available, <italic>AA</italic>-genotype showed lower waist circumference (−6.86 cm, <italic>P</italic> = 0.008) and triglycerides levels (−5.58 mg/100 mL, <italic>P</italic> < 0.002) when compared to <italic>G-allele</italic> carriers. Finally, waist-to-hip ratio was associated with <italic>rs6070157</italic> (proxy of <italic>rs11552145</italic>, r<sup>2</sup> = 0.99) in a population-based sample (N = 123, 865, <italic>P</italic> = 0.022). Our results suggest an association of <italic>rs11552145G > A</italic> polymorphism with metabolic-related traits, especially in psychiatric populations and in women younger than 45 years.</p> </sec> </abstract>