Circulating Biomarkers and Abdominal Aortic Aneurysm Incidence. Issue 7 (18th August 2015)

• Record Type: Journal Article
• Authors: Folsom, Aaron R.; Yao, Lu; Alonso, Alvaro; Lutsey, Pamela L.; Missov, Emil; Lederle, Frank A.; Ballantyne, Christie M.; Tang, Weihong
• Is Part Of: Circulation. Volume 132:Issue 7(2015)
• Publication Date: 2015-08-18
• Subjects: Blood -- Circulation -- Periodicals; Cardiovascular system -- Periodicals; Cardiology -- Periodicals; Heart -- Diseases -- Periodicals; Blood Circulation; Cardiovascular System; Vascular Diseases; 616.1
• DOI: 10.1161/CIRCULATIONAHA.115.016537
• Languages: English
• ISSNs: 0009-7322

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Background—</title> <p>The pathogenesis of abdominal aortic aneurysm (AAA) is complex. Cross-sectional studies have connected circulating biomarkers with AAA, but prospective evidence is limited.</p> </sec> <sec> <title>Methods and Results—</title> <p>In the Atherosclerosis Risk in Communities Study cohort, we measured multiple blood biomarkers of inflammation, hemostasis, thrombin generation, cardiac dysfunction, and vascular stiffness and identified incident AAAs during follow-up using hospital discharge codes. Six biomarkers (white blood cell count, fibrinogen, D-dimer, troponin T, N-terminal pro-brain natriuretic peptide, and high-sensitivity C-reactive protein) were strongly associated positively with AAA incidence. Compared with having none of these 6 biomarkers in the highest quartile, the hazard ratios of AAA for those with 1, 2, 3, or 4 to 6 biomarkers in the highest quartile were 2.2, 3.3, 4.0, and 9.9, respectively (<italic>P</italic> for trend &lt; 0.0001) after adjustment for other risk factors.</p> </sec> <sec> <title>Conclusions—</title> <p>This prospective study found that higher concentrations of 6 biomarkers were associated with increased risk of AAA. The more markers that fell into the highest quartile, the higher the AAA risk was. Multiple positive biomarkers identify a subgroup of patients at high risk of AAA.</p> </sec> </abstract>