Generalized severe junctional epidermolysis bullosa with congenital absence of skin in churra lambs. Issue 5 (10th June 2015)

• Record Type: Journal Article
• Authors: Benavides, Julio; Suárez‐Vega, Aroa; Gutiérrez, Jorge; de la Hera, Sandra; Fuertes, Miguel; Delgado, Laetitia; Fernández, Miguel; Ferreras, María del Carmen; Arranz, Juan José; Pérez, Valentín
• Is Part Of: Veterinary dermatology. Volume 26:Issue 5(2015)
• Page Start: 367
• Page End: e83
• Publication Date: 2015-06-10
• Subjects: Veterinary dermatology -- Periodicals; Pet medicine -- Periodicals; 636.08965
• DOI: 10.1111/vde.12226
• Languages: English
• ISSNs: 0959-4493

Abstract

<abstract abstract-type="main" id="vde12226-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="vde12226-sec-0001" sec-type="section"> <title>Background</title> <p>Up to 0.5% of churra lambs from two genetically related flocks showed congenital skin lesions of variable severity, jeopardizing the life of the lambs in the most severe cases.</p> </sec> <sec id="vde12226-sec-0002" sec-type="section"> <title>Hypothesis/Objectives</title> <p>The primary objective of this study was to classify the type of congenital epithelial disease suffered by these animals, based on the description of the macroscopic skin defects, the histological and ultrastructural changes and the hereditary nature of the condition.</p> </sec> <sec id="vde12226-sec-0003" sec-type="section"> <title>Animals</title> <p>Thirty affected newborn lambs from two genetically related flocks were studied. Three additional lambs acquired from two other flocks, which had no grossly apparent skin lesions and had died of infectious diseases, were studied as unaffected control animals.</p> </sec> <sec id="vde12226-sec-0004" sec-type="section"> <title>Methods</title> <p>Histological and ultrastructural examinations of skin and oral mucosa samples were performed. Pedigree analyses were used to investigate genealogical relationships.</p> </sec> <sec id="vde12226-sec-0005" sec-type="section"> <title>Results</title> <p>Generalized severe junctional epidermolysis bullosa with congenital absence of skin was described in all lambs studied and an autosomal recessive mode of inheritance was identified.</p> </sec> <sec id="vde12226-sec-0006" sec-type="section"> <title>Conclusions and clinical importance</title> <p>The pathological findings and mode of inheritance in these lambs are similar to an inherited epidermolysis bullosa subtype of humans, which has not been reported previously in veterinary medicine.</p> </sec> </abstract>