Microenvironmental control of stem cell fate in intestinal homeostasis and disease. Issue 2 (15th June 2015)

• Record Type: Journal Article
• Authors: Biswas, Sujata; Davis, Hayley; Irshad, Shazia; Sandberg, Tessa; Worthley, Daniel; Leedham, Simon
• Is Part Of: Journal of pathology. Volume 237:Issue 2(2015)
• Page Start: 135
• Page End: 145
• Publication Date: 2015-06-15
• Subjects: Pathology -- Periodicals; 616.07
• DOI: 10.1002/path.4563
• Languages: English
• ISSNs: 0022-3417

Abstract

<abstract abstract-type="main" id="path4563-abs-0001"> <title>Abstract</title> <p id="path4563-para-0001">The conventional model of intestinal epithelial architecture describes a unidirectional tissue organizational hierarchy with stem cells situated at the crypt base and daughter cells proliferating and terminally differentiating as they progress along the vertical (crypt–luminal) axis. In this model, the fate of a cell that has left the niche is determined and its lifespan limited. Evidence is accumulating to suggest that stem cell control and daughter cell fate determination is not solely an intrinsic, cell autonomous property but is heavily influenced by the microenvironment including paracrine, mesenchymal, and endogenous epithelial morphogen gradients. Recent research suggests that in intestinal homeostasis, stem cells transit reversibly between states of variable competence in the niche. Furthermore, selective pressures that disrupt the homeostatic balance, such as intestinal inflammation or morphogen dysregulation, can cause committed progenitor cells and even some differentiated cells to regain stem cell properties. Importantly, it has been recently shown that this disruption of cell fate determination can lead to somatic mutation and neoplastic transformation of cells situated outside the crypt base stem cell niche. This paper reviews the exciting developments in the study of stem cell dynamics in homeostasis, intestinal regeneration, and carcinogenesis, and explores the implications for human disease and cancer therapies. © 2015 Authors. <italic>The Journal of Pathology</italic> published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.</p> </abstract>