The Association of Fibrinous Pleural Effusion with Survival and Complications in Horses with Pleuropneumonia (2002–2012): 74 Cases. (11th August 2015)

• Record Type: Journal Article
• Authors: Tomlinson, J.E.; Reef, V.B.; Boston, R.C.; Johnson, A.L.
• Is Part Of: Journal of veterinary internal medicine. Volume 29:Number 5(2015:Sep./Oct.)
• Page Start: 1410
• Page End: 1417
• Publication Date: 2015-08-11
• Subjects: Veterinary medicine -- Periodicals; 636.0896
• DOI: 10.1111/jvim.13591
• Languages: English
• ISSNs: 0891-6640

Abstract

<abstract abstract-type="main" id="jvim13591-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jvim13591-sec-0001" sec-type="section"> <title>Background</title> <p>Fibrinous parapneumonic pleural effusions are associated with decreased efficacy of pleural fluid drainage and increased risk of medical treatment failure in people, but similar associations have not been established in horses.</p> </sec> <sec id="jvim13591-sec-0002" sec-type="section"> <title>Hypothesis/Objectives</title> <p>We hypothesized that fibrin deposition in the pleural cavity of horses with parapneumonic effusions increases the risk of poor outcome.</p> </sec> <sec id="jvim13591-sec-0003" sec-type="section"> <title>Animals</title> <p>Seventy four horses with bacterial pleuropneumonia diagnosed by culture and cytology of tracheal aspirates, pleural fluid, or both, and pleural effusion diagnosed by ultrasonographic examination.</p> </sec> <sec id="jvim13591-sec-0004" sec-type="section"> <title>Methods</title> <p>Retrospective study of cases was from 2002 to 2012. Information obtained from the medical records included signalment, history, sonographic findings, treatments, and outcome. The primary outcome investigated was survival and secondary outcomes were development of complications and surgical intervention. Fisher's exact test and logistic regression were applied for categorical variables. A <italic>t</italic>‐test was used to find differences in continuous variables between groups.</p> </sec> <sec id="jvim13591-sec-0005" sec-type="section"> <title>Results</title> <p>Seventy four horses met study criteria and 50 (68%) survived. Fibrinous pleural effusion was associated with higher respiratory rate and pleural fluid height at admission, necrotizing pneumonia, increased number of indwelling thoracic drains required for treatment, and decreased survival.</p> </sec> <sec id="jvim13591-sec-0006" sec-type="section"> <title>Conclusions and clinical importance</title> <p>Fibrin accumulation in parapneumonic effusions is associated with increased mortality. Direct fibrinolytic treatment might be indicated in affected horses.</p> </sec> </abstract>