Hypercoagulability and the risk of myocardial infarction and ischemic stroke in young women. (21st August 2015)

• Record Type: Journal Article
• Authors: Siegerink, B.; Maino, A.; Algra, A.; Rosendaal, F. R.
• Is Part Of: Journal of thrombosis and haemostasis. Volume 13:Number 9(2015:Sep.)
• Page Start: 1568
• Page End: 1575
• Publication Date: 2015-08-21
• Subjects: Thrombosis -- Periodicals; Hemostasis -- Periodicals; Blood coagulation disorders -- Periodicals; 616.1
• DOI: 10.1111/jth.13045
• Languages: English
• ISSNs: 1538-7933

Abstract

<abstract abstract-type="main" id="jth13045-abs-0001"> <title>Summary</title> <sec id="jth13045-sec-0001" sec-type="section"> <title>Background</title> <p>Myocardial infarction (MI) and ischemic stroke (IS) are acute forms of arterial thrombosis and share some, but not all, risk factors, indicating different pathophysiological mechanisms.</p> </sec> <sec id="jth13045-sec-0002" sec-type="section"> <title>Objective</title> <p>This study aims to determine if hypercoagulability has a differential effect on the risk of MI and IS.</p> </sec> <sec id="jth13045-sec-0003" sec-type="section"> <title>Patients and methods</title> <p>We reviewed the results from the Risk of Arterial Thrombosis in Relation to Oral Contraceptives study, a population‐based case–control study involving young women (< 50 years) with MI, non‐cardioembolic IS and healthy controls.</p> <p>From these data, relative odds ratios (OR<sub>IS</sub>/OR<sub>MI</sub>) and their corresponding confidence intervals for all prothrombotic factors that were studied in both subgroups were calculated.</p> </sec> <sec id="jth13045-sec-0004" sec-type="section"> <title>Results</title> <p>Twenty‐nine prothrombotic risk factors were identified as measures of hypercoagulability. Twenty‐two of these risk factors (21/29, 72%) had a relative odds ratios > 1; for 12 (41%), it was > 2; and for 5 (17%), it was > 2.75. The five risk factors with the largest differences in associations were high levels of activated factor XI (FXI) and FXII, kallikrein, the presence of lupus anticoagulans, and a genetic variation in the <italic>FXIII</italic> gene.</p> </sec> <sec id="jth13045-sec-0005" sec-type="section"> <title>Conclusion</title> <p>In young women, prothrombotic factors are associated more with the risk of IS than with MI risk, suggesting a different role of hypercoagulability in the mechanism leading to these two diseases.</p> </sec> </abstract>