Ambient air pollutant PM10 and risk of pregnancy-induced hypertension in urban China. (August 2015)

• Record Type: Journal Article
• Authors: Huang, Xin; Qiu, Jie; Zhang, Yaqun; Qiu, Weitao; He, Xiaochun; Wang, Yixuan; Sun, Qingmei; Zhao, Nan; Cui, Hongmei; Liu, Sufen; Tang, Zhongfeng; Chen, Ya; Yue, Li; Da, Zhenqiang; Lv, Ling; Lin, Xiaojuan; Zhang, Chong; Zhang, Honghong; Xu, Ruifeng; Zhu, Daling; Xu, Xiaoying; Lin, Ru; Yao, Tingting; Su, Jie; Dang, Yun; Han, Xudong; Zhang, Hanru; Bai, Haiya; Wang, Wendi; Wang, Yueyuan; Liu, Xiaohui; Ma, Bin; Huang, Huang; Liang, Jiaxin; Jiang, Min; Ma, Shuangge; Bell, Michelle L; Kim, Christopher; Liu, Qing; Zhang, Yawei;
• Is Part Of: Environmental research letters. Volume 10:Number 8(2015:Aug.)
• Page Start: 36
• Page End: 44
• Publication Date: 2015-08
• Subjects: Environmental sciences -- Periodicals; Human ecology -- Research -- Periodicals; Environmental health -- Periodicals; 333.7
• DOI: 10.1088/1748-9326/10/8/084025
• Languages: English
• ISSNs: 1748-9326

Abstract

<abstract> <title>Abstract</title> <p> <italic>Background</italic>: The relationship between air borne particulate matter ≤10 <italic>μ</italic>m (PM<sub>10</sub>) exposure and pregnancy-induced hypertension (PIH) is inconclusive. Few studies have been conducted, and fewer were conducted in areas with high levels of PM<sub>10</sub>. <italic>Methods</italic>: To examine the association between PM<sub>10</sub> and PIH by different exposure time windows during pregnancy, we analyzed data from a birth cohort study conducted in Lanzhou, China including 8 745 pregnant women with available information on air pollution during pregnancy. A total of 333 PIH cases (127 gestational hypertension (GH) and 206 preeclampsia (PE)) were identified. PM<sub>10</sub> daily average concentrations of each subject were calculated according to the distance between home/work addresses and monitor stations using an inverse-distance weighting approach. <italic>Results</italic>: Average PM<sub>10</sub> concentration over the duration of entire pregnancy was significantly associated with PIH (OR = 1.12, 95%CI: 1.02, 1.23 per 10 <italic>μ</italic>g m<sup>−3</sup> increase), PE (OR = 1.16, 95%CI: 1.03, 1.30 per 10 <italic>μ</italic>g m<sup>−3</sup> increase), late onset PE (OR = 1.17, 95% CI: 1.03, 1.32 per10 <italic>μ</italic>g m<sup>−3</sup> increase), and severe PE (OR = 1.25, 95% CI: 1.06, 1.48 per 10 <italic>μ</italic>g m<sup>−3</sup> increase). Average PM<sub>10</sub> during the first 12 gestational weeks was associated with the risk of GH (OR = 1.10, 95% CI: 1.00, 1.21 per 10 <italic>μ</italic>g m<sup>−3</sup> increase), and PM<sub>10</sub> exposure before 20 gestational weeks was associated with the risk of severe PE (OR = 1.14, 95% CI: 1.01, 1.30 per 10 <italic>μ</italic>g m<sup>−3</sup> increase). <italic>Conclusions</italic>: We found that high level exposure to ambient PM<sub>10</sub> during pregnancy was associated with an increased risk of PIH, GH and PE and that the strength of the association varied by timing of exposure during pregnancy.</p> </abstract>