A Rac1 GTPase is a critical factor in the immune response of shrimp (Litopenaeus vannamei) to Vibrio alginolyticus infection. Issue 2 (August 2015)

• Record Type: Journal Article
• Authors: Cha, Gui-Hong; Wang, Wei-Na; Peng, Ting; Huang, Ming-Zhu; Liu, Yuan
• Is Part Of: Developmental and comparative immunology. Volume 51:Issue 2(2015)
• Page Start: 226
• Page End: 237
• Publication Date: 2015-08
• Subjects: Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2015.04.004
• Languages: English
• ISSNs: 0145-305X

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">The <italic>Lv</italic>Rac1 gene cloned from <italic>Litopenaeus vannamei</italic> was most highly expressed in hemolymph.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Transcript of <italic>Lv</italic>Rac1 was markedly increased after challenge with <italic>Vibrio alginolyticus</italic>.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Silencing <italic>LvRac1</italic> by dsRNA reduced both the transcription of <italic>Lv</italic>p53 and <italic>Lv</italic>Cu/ZnSOD.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">The mortality of Rac1 silenced shrimp during <italic>Vibrio alginolyticus</italic> infection increased significantly.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">Evidences indicate that <italic>Lv</italic>Rac1 may play a role in shrimp immune response against <italic>Vibrio alginolyticus</italic>.</p> </list-item> </list> </p> </sec> </abstract>