Disease map-based biomarker selection and pre-validation for bladder cancer diagnostic. (July 2015)

• Record Type: Journal Article
• Authors: De Paoli, Marine; Perco, Paul; Mühlberger, Irmgard; Lukas, Arno; Pandha, Hardev; Morgan, Richard; Feng, Gui Jie; Marquette, Christophe
• Is Part Of: Biomarkers. Volume 20:Number 5(2015)
• Page Start: 328
• Page End: 337
• Publication Date: 2015-07
• Subjects: Biochemical markers -- Periodicals; 610.28
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Context</italic>: Urinary biomarkers are promising as simple alternatives to cystoscopy for the diagnosis of <italic>de novo</italic> and recurrent bladder cancer.</p> <p> <italic>Objective</italic>: To identify a highly sensitive and specific biomarker candidate set with potential clinical utility in bladder cancer.</p> <p> <italic>Materials and methods</italic>: Urinary biomarker concentrations were determined by ELISA. The performance of individual markers and marker combinations was assessed using ROC analysis.</p> <p> <italic>Results</italic>: A five-biomarker panel (IL8, MMP9, VEGFA, PTGS2 and EN2) was defined from the candidate set.</p> <p> <italic>Discussion and conclusion</italic>: This panel showed a better overall performance than the best individual marker. Further validation studies are needed to evaluate its clinical utility in bladder cancer.</p> </abstract>