New immunotherapies targeting the PD-1 pathway. (September 2015)

• Record Type: Journal Article
• Authors: Chinai, Jordan M.; Janakiram, Murali; Chen, Fuxiang; Chen, Wantao; Kaplan, Mark; Zang, Xingxing
• Is Part Of: Trends in pharmacological sciences. Volume 36:Number 9(2015)
• Page Start: 587
• Page End: 595
• Publication Date: 2015-09
• Subjects: Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2015.06.005
• Languages: English
• ISSNs: 0165-6147

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">PD-1 is a coinhibitory receptor found on T cells and other immune cells.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">PD-L1 and PD-L2 are ligands for PD-1.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">PD-1 ligation leads to impaired T cell function in cancer and chronic infections.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Blocking PD-1 and PD-L1 successfully treats some human cancers.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Blocking PD-1 can treat chronic viral infections.</p> </list-item> </list> </p> </sec> </abstract>