Complex host genetic susceptibility to Staphylococcus aureus infections. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Shukla, Sanjay K.; Rose, Warren; Schrodi, Steven J.
• Is Part Of: Trends in microbiology. Volume 23:Issue 9(2015)
• Page Start: 529
• Page End: 536
• Publication Date: 2015-09
• Subjects: Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2015.05.008
• Languages: English
• ISSNs: 0966-842X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Great care is needed to select cases and controls for genetic studies of <italic>Staphylococcus aureus</italic> infection.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Infection susceptibility involves cell adhesion, invasion, and innate and adaptive immunity.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Genetics of <italic>S. aureus</italic> carriage and severe infection involves different host factors.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Susceptibility to <italic>S. aureus</italic> infections is polygenic due to pathogen versatility.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025"> <italic>S. aureus</italic> infection severity, trajectory, and tissue specificity are polygenic.</p> </list-item> </list> </p> </sec> </abstract>