Estrogen receptor mutations and functional consequences for breast cancer. (September 2015)

• Record Type: Journal Article
• Authors: Thomas, Christoforos; Gustafsson, Jan-Åke
• Is Part Of: Trends in endocrinology and metabolism. Volume 26:Number 9(2015)
• Page Start: 467
• Page End: 476
• Publication Date: 2015-09
• Subjects: Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2015.06.007
• Languages: English
• ISSNs: 1043-2760

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">There is a substantial frequency of <italic>ESR1</italic> point mutations in metastatic breast tumors.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010"> <italic>ESR1</italic> mutations are implicated in clinical resistance to hormonal therapy.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015"> <italic>ESR1</italic> mutations render receptor activity constitutive by altering receptor conformation.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Early detection of the mutations can guide proper selection of therapy.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Novel therapeutics to overcome resistance conferred by the mutations are being tested.</p> </list-item> </list> </p> </sec> </abstract>