Prevalence of abdominal aortic calcifications in older living renal donors and its effect on graft function and histology. (4th June 2015)

• Record Type: Journal Article
• Authors: Wu, En‐Haw; Wojciechowski, David; Chandran, Sindhu; Yeh, Benjamin M.; Park, Meyeon; Westphalen, Antonio; Wang, Zhen J.
• Is Part Of: Transplant international. Volume 28:Number 10(2015:Oct.)
• Page Start: 1172
• Page End: 1178
• Publication Date: 2015-06-04
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/tri.12612
• Languages: English
• ISSNs: 0934-0874

Abstract

<abstract abstract-type="main" id="tri12612-abs-0001"> <title>Summary</title> <p>We assessed the prevalence of abdominal aortic calcification (AAC) in older living kidney donors and its effect on recipient eGFR and graft histology. A total of 292 consecutive living pairs with donor age ≥50 from 2003 to 2013 were identified (mean age 56; range 50–78; F/M: 1.8). Donor AAC was determined by prenephrectomy unenhanced CT. Recipient eGFR and spot urine protein: creatinine ratios (UPCRs) were recorded. A total of 180 recipients had 6‐month protocol biopsies. AAC was present in 40.7% of donors, and they were older (58.6 versus 54.7 years old, <italic>P</italic> < 0.0001) and more likely to be male (77.6% vs. 37.3%, <italic>P</italic> = 0.004). There was no significant difference in eGFR or spot UPCR up to 36 months in recipients of allografts from donors with versus without AAC. At 6‐month biopsy, there was a higher percentage of allografts with vascular fibrous intimal thickening and arteriolar hyaline thickening from donors with versus without AAC (vascular fibrous intimal thickening: 38.8% vs. 7.1% and arteriolar hyaline thickening: 35.8% vs. 7.1%; <italic>P</italic> < 0.001 for both). The presence of donor AAC predicts the presence of vascular disease [vascular fibrous intimal thickening (OR: 7.2; CI:2.9–17.9) and arteriolar hyaline thickening (OR:5.7; CI:2.3–14.1)] in allografts at 6 months. Donor AAC is predictive of renal vascular disease and may help to improve the screening of potential donors and inform post‐transplant management.</p> </abstract>