Graft function 1 year after pregnancy in an islet‐transplanted patient. (11th May 2015)

• Record Type: Journal Article
• Authors: Schive, Simen W.; Scholz, Hanne; Sahraoui, Afaf; Kloster‐Jensen, Kristine; Hafsahl, Geir; Korsgren, Olle; Foss, Aksel; Jenssen, Trond G.
• Is Part Of: Transplant international. Volume 28:Number 10(2015:Oct.)
• Page Start: 1235
• Page End: 1239
• Publication Date: 2015-05-11
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/tri.12596
• Languages: English
• ISSNs: 0934-0874

Abstract

<abstract abstract-type="main" id="tri12596-abs-0001"> <title>Summary</title> <p>Pancreatic islet transplantation is a treatment option for patients with type 1 diabetes (T1D), but pregnancy has generally not been advised for women after receiving an islet allograft. We hereby describe what is to our knowledge the first successful pregnancy and persistent graft function in a woman 4 years after her initial islet transplantation. A 37‐year‐old woman with brittle type 1 diabetes was transplanted with two separate islet graft infusions, eventually becoming insulin independent. Ten months after her second transplantation, her immunosuppression was switched from tacrolimus and sirolimus to tacrolimus, azathioprine, and prednisolone, due to her wish to become pregnant. She became pregnant one year later, and after 38 weeks of uncomplicated pregnancy, she gave birth to a healthy child by C‐section. The current report suggests that pregnancy and childbirth can be accomplished after islet transplantation without loss of islet graft function.</p> </abstract>