Differential role of gene hypermethylation in adenocarcinomas, squamous cell carcinomas and cervical intraepithelial lesions of the uterine cervix. (27th July 2015)

• Record Type: Journal Article
• Authors: Blanco‐Luquin, Idoia; Guarch, Rosa; Ojer, Amaya; Pérez‐Janices, Noemí; Martín‐Sánchez, Esperanza; Maria‐Ruiz, Sergio; Monreal‐Santesteban, Iñaki; Blanco‐Fernandez, Laura; Pernaut‐Leza, Eduardo; Escors, David; Guerrero‐Setas, David
• Is Part Of: Pathology international. Volume 65:Number 9(2015:Sep.)
• Page Start: 476
• Page End: 485
• Publication Date: 2015-07-27
• Subjects: Pathology -- Periodicals; 616.07
• DOI: 10.1111/pin.12332
• Languages: English
• ISSNs: 1320-5463

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Cervical cancer is the third most common cancer in women worldwide. The hypermethylation of <italic>P16</italic>, <italic>TSLC‐1</italic> and <italic>TSP‐1</italic> genes was analyzed in squamous cell carcinomas (SCC), cervical intraepithelial lesions (CIN) and adenocarcinomas (ADC) of the uterine cervix (total 181 lesions). Additionally human papillomavirus (HPV) type, <italic>EPB41L3, RASSF1</italic> and <italic>RASSF2</italic> hypermethylation were tested in ADC and the results were compared with those obtained previously by our group in SCC. <italic>P16</italic>, <italic>TSLC‐1</italic> and <italic>TSP‐1</italic> hypermethylation was more frequent in SCCs than in CINs. These percentages and the corresponding ones for <italic>EPB41L3</italic>, <italic>RASSF1</italic> and <italic>RASSF2</italic> genes were also higher in SCCs than in ADCs, except for <italic>P16</italic>. The presence of HPV in ADCs was lower than reported previously in SCC and CIN. Patients with <italic>RASSF1A</italic> hypermethylation showed significantly longer disease‐free survival (<italic>P</italic> = 0.015) and overall survival periods (<italic>P</italic> = 0.009) in ADC patients. To our knowledge, this is the first description of the <italic>EPB41L3</italic> and <italic>RASSF2</italic> hypermethylation in ADCs. These results suggest that the involvement of DNA hypermethylation in cervical cancer varies depending on the histological type, which might contribute to explaining the different prognosis of patients with these types of tumors.</p> </abstract>