Impact of an experimental PRRSV and Streptococcus suis coinfection on the pharmacokinetics of ceftiofur hydrochloride after intramuscular injection in pigs1. Issue 5 (16th February 2015)

• Record Type: Journal Article
• Authors: Day, D. N.; Sparks, J. W.; Karriker, L. A.; Stalder, K. J.; Wulf, L. W.; Zhang, J.; Kinyon, J. M.; Stock, M. L.; Gehring, R.; Wang, C.; Ellingson, J.; Coetzee, J. F.
• Is Part Of: Journal of veterinary pharmacology and therapeutics. Volume 38:Issue 5(2015)
• Page Start: 475
• Page End: 481
• Publication Date: 2015-02-16
• Subjects: Veterinary pharmacology -- Periodicals; Therapeutics -- Periodicals; 636.0895105
• DOI: 10.1111/jvp.12209
• Languages: English
• ISSNs: 0140-7783

Abstract

<abstract abstract-type="main" id="jvp12209-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>This study determined the impact of porcine reproductive and respiratory syndrome virus (PRRSV) and <italic>Streptococcus suis</italic> coinfection on the pharmacokinetic (PK) profile of ceftiofur hydrochloride in pigs after intramuscular (i.m.) injection. Eighteen clinically normal crossbred gilts were assigned by weight into a challenge group (10 pigs) and control group (eight pigs). Pigs in both groups received a single i.m. injection of ceftiofur hydrochloride (Excenel RTU Sterile Suspension; Zoetis) at a 5 mg/kg BW dose. Serial blood samples were collected to characterize the plasma concentration curve. After a 10 days drug washout period, the challenge group was inoculated with 2 mL of PRRSV isolate VR‐2385 (10^5.75 50% tissue culture infective doses per mL) intranasally and 8 days later inoculated <italic>S. suis</italic>. When clinical disease was evident, the second PK assessment began in both challenge and control groups. Coinfected pigs demonstrated lower values of AUC and C_MAX, but higher values of Cl/F and Vz/F indicating drug kinetics were altered by infection. The data from this study have implications on ceftiofur treatment regimens in diseased pigs.</p> </abstract>