Polycystic kidney disease in four British shorthair cats with successful treatment of bacterial cyst infection. (12th February 2015)

• Record Type: Journal Article
• Authors: Nivy, R.; Lyons, L. A.; Aroch, I.; Segev, G.
• Is Part Of: Journal of small animal practice. Volume 56:Number 9(2015:Sep.)
• Page Start: 585
• Page End: 589
• Publication Date: 2015-02-12
• Subjects: Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; 636.089
• DOI: 10.1111/jsap.12327
• Languages: English
• ISSNs: 0022-4510

Abstract

<abstract abstract-type="main" id="jsap12327-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="jsap12327-para-0001">Polycystic kidney disease is the most common inherited disorder in cats. Renal cysts progressively increase in size and number, resulting in a gradual decrease in kidney function. An autosomal dominant mutation in exon 29 of the <italic>polycystin‐1</italic> gene has been identified, mostly in Persian and Persian‐related breeds. This case study describes polycystic kidney disease in four British shorthair cats, of which two had the same genetic mutation reported in Persian and Persian‐related cats. This likely reflects introduction of this mutation into the British shorthair breeding line because of previous outcrossing with Persian cats. An infected renal cyst was diagnosed and successfully treated in one of the cats. This is a commonly reported complication in human polycystic kidney disease, and to the authors' knowledge has not previously been reported in cats with polycystic kidney disease.</p> </abstract>