An Enantioselective Synthesis of Spirobilactams through Copper‐Catalyzed Intramolecular Double N‐Arylation and Phase Separation. (23rd July 2015)

• Record Type: Journal Article
• Authors: Liu, Jianguang; Tian, Yingying; Shi, Jialing; Zhang, Shasha; Cai, Qian
• Is Part Of: Angewandte Chemie. Volume 127:Number 37(2015)
• Page Start: 11067
• Page End: 11070
• Publication Date: 2015-07-23
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201504589
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Spirobicyclic structures are versatile building blocks for functional chiral molecules. An enantioselective synthesis of chiral spirobilactams via a copper‐catalyzed double N‐arylation was developed. Amplification of solution <italic>ee</italic> by in situ precipitation of the racemate was observed with this method and enantioenriched spirobilactams were obtained with excellent <italic>ee</italic> values through simple solid–solution phase separation.</p> </abstract>