A Small‐Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson's Disease. Issue 37 (21st July 2015)

• Record Type: Journal Article
• Authors: Li, Lin; Zhang, Cheng‐Wu; Ge, Jingyan; Qian, Linghui; Chai, Bing‐Han; Zhu, Qing; Lee, Jun‐Seok; Lim, Kah‐Leong; Yao, Shao Q.
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 37(2015)
• Page Start: 10821
• Page End: 10825
• Publication Date: 2015-07-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201504441
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The design of the first dual‐purpose activity‐based probe of monoamine oxidase B (MAO‐B) is reported. This probe is highly selective towards MAO‐B, even at high MAO‐A expression levels, and could sensitively report endogenous MAO‐B activities by both in situ proteome profiling and live‐cell bioimaging. With a built‐in imaging module as part of the probe design, the probe was able to accomplish what all previously reported MAO‐B imaging probes failed to do thus far: the live‐cell imaging of MAO‐B activities without encountering diffusion problems.</p> </abstract>