Treatment of Hypertension in Children With Catecholamine‐Secreting Tumors: A Systematic Approach. Issue 9 (23rd May 2015)

• Record Type: Journal Article
• Authors: Romero, Mauricio; Kapur, Gaurav; Baracco, Rossana; Valentini, Rudolph P.; Mattoo, Tej K.; Jain, Amrish
• Is Part Of: Journal of clinical hypertension. Volume 17:Issue 9(2015:Sep.)
• Page Start: 720
• Page End: 725
• Publication Date: 2015-05-23
• Subjects: Hypertension -- Periodicals; 616.132
• DOI: 10.1111/jch.12571
• Languages: English
• ISSNs: 1524-6175

Abstract

<abstract abstract-type="main" id="jch12571-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Management of blood pressure in children with pheochromocytoma and other catecholamine‐secreting tumors (CSTs) is unique and challenging. The authors report a single‐center experience using sequential α‐adrenergic blockade (phenoxybenzamine), increased fluid intake, and β‐blockade for presurgical management of 10 CSTs in children. In this retrospective review, mean duration for blood pressure control in preparation for surgery was 4.5±2.6 weeks. Intraoperative hypertension was noted transiently (&lt;2 hours) in eight patients (80%) and was treated with continuous infusion of short‐acting antihypertensive agents. Two (20%) patients required vasopressor medication infusion to manage intraoperative hypotension. Only two (20%) patients developed postoperative hypotension and required vasopressor medication infusion for &lt;24 hours. All antihypertensive medications were discontinued in the immediate (≤4 days) postoperative period in 80% of patients. In conclusion, a systematic and multidisciplinary approach utilizing adrenergic blockade is effective in treating children with CSTs.</p> </abstract>