Association between serum osteocalcin level and visceral obesity in Chinese postmenopausal women. (7th May 2015)

• Record Type: Journal Article
• Authors: Luo, Yuqi; Ma, Xiaojing; Hao, Yaping; Xu, Yiting; Xiong, Qin; Tang, Junling; Pan, Xiaoping; Xiao, Yunfeng; Bao, Yuqian; Jia, Weiping
• Is Part Of: Clinical endocrinology. Volume 83:Number 3(2015:Sep.)
• Page Start: 429
• Page End: 434
• Publication Date: 2015-05-07
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.12793
• Languages: English
• ISSNs: 0300-0664

Abstract

<abstract abstract-type="main" id="cen12793-abs-0001"> <title>Summary</title> <sec id="cen12793-sec-0001" sec-type="section"> <title>Background</title> <p>A low serum osteocalcin level, visceral obesity and postmenopausal status are recognized risk factors for cardiovascular disease.</p> </sec> <sec id="cen12793-sec-0002" sec-type="section"> <title>Objective</title> <p>We investigated the relationship between the serum osteocalcin level and visceral fat content in a population of Chinese postmenopausal women.</p> </sec> <sec id="cen12793-sec-0003" sec-type="section"> <title>Design and patients</title> <p>In total, 1481 postmenopausal women (mean age ± standard deviation, 57·1 ± 4·8 years) were selected from the Shanghai Obesity Study.</p> </sec> <sec id="cen12793-sec-0004" sec-type="section"> <title>Measurements</title> <p>Abdominal fat accumulation was quantified using magnetic resonance imaging. Subjects with a visceral fat area (VFA) of ≥80 cm<sup>2</sup> were classified as abdominally obese. The total serum osteocalcin level was measured by electrochemiluminescence immunoassay.</p> </sec> <sec id="cen12793-sec-0005" sec-type="section"> <title>Results</title> <p>The median serum osteocalcin level was 20·66 μg/l (interquartile range, 16·88–25·42 μg/l). The overall prevalence of abdominal obesity was 49·1% (<italic>n</italic> = 727). Abdominally obese subjects had lower serum osteocalcin levels than did nonabdominally obese subjects [19·14 (16·02–23·82) <italic>vs</italic> 21·97 (18·14–26·77) μg/l, respectively; <italic>P </italic><<italic> </italic>0·001]. Partial correlation analysis showed that the serum osteocalcin level was still negatively correlated with VFA after adjusting for age, years since menopause and body mass index (<italic>P </italic><<italic> </italic>0·01). Moreover, VFA was independently associated with the serum osteocalcin level after adjustment for confounding factors (<italic>P </italic><<italic> </italic>0·05). A low serum osteocalcin level was an independent risk factor for abdominal obesity (odds ratio, 0·972; 95% confidence interval, 0·953–0·991; <italic>P </italic>=<italic> </italic>0·004).</p> </sec> <sec id="cen12793-sec-0006" sec-type="section"> <title>Conclusion</title> <p>The serum osteocalcin level was inversely correlated with the visceral fat content in these Chinese postmenopausal women.</p> </sec> </abstract>