The Effects of Arterial Hypertension and Age on the Sublingual Microcirculation of Healthy Volunteers and Outpatients with Cardiovascular Risk Factors. (August 2015)

• Record Type: Journal Article
• Authors: Kanoore Edul, Vanina S.; Ince, Can; Estenssoro, Elisa; Ferrara, Gonzalo; Arzani, Yanina; Salvatori, Carolina; Dubin, Arnaldo
• Is Part Of: Microcirculation. Volume 22:Number 6(2015:Aug.)
• Page Start: 485
• Page End: 492
• Publication Date: 2015-08
• Subjects: Biological transport -- Periodicals; Microcirculation -- Physiology -- Periodicals; 612.135
• DOI: 10.1111/micc.12219
• Languages: English
• ISSNs: 1073-9688

Abstract

<abstract abstract-type="main" id="micc12219-abs-0001"> <title>Abstract</title> <sec id="micc12219-sec-0001" sec-type="section"> <title>Objectives</title> <p>To quantitatively assess the effects of age, blood pressure, chronic arterial hypertension, and physical activity on sublingual microcirculation in ambulatory volunteers.</p> </sec> <sec id="micc12219-sec-0002" sec-type="section"> <title>Methods</title> <p>Sublingual microcirculation was assessed in 61 volunteers with or without chronic arterial hypertension.</p> </sec> <sec id="micc12219-sec-0003" sec-type="section"> <title>Results</title> <p>Volunteers with chronic arterial hypertension had lower TVD<sub>all vessels</sub>, and TVD<sub>small vessels</sub> and PVD<sub>small vessels</sub> than those without this condition (16.0 ± 1.4 vs. 17.2 ± 1.6 mm/mm<sup>2</sup>, <italic>p </italic><<italic> </italic>0.01, 15.1 ± 1.3 vs. 16.1 ± 1.7 mm/mm<sup>2</sup>, <italic>p </italic><<italic> </italic>0.04, and 15.1 ± 1.3 vs. 16.1 ± 1.7 mm/mm<sup>2</sup>, <italic>p </italic><<italic> </italic>0.04, respectively). Mean blood pressure correlated with TVD<sub>all vessels</sub> (<italic>r</italic> = −0.34, <italic>p </italic><<italic> </italic>0.01), TVD<sub>small vessels</sub> (<italic>r</italic> = −0.31, <italic>p </italic><<italic> </italic>0.02), and PVD<sub>small vessels</sub> (<italic>r</italic> = −0.27, <italic>p </italic><<italic> </italic>0.04) but not with other microvascular variables. Age was not correlated with any microcirculatory variables. Physical activity correlated with TVD<sub>all vessels</sub> and RBCV<sub>small vessels</sub> (<italic>r</italic> = 0.30, <italic>p </italic><<italic> </italic>0.02 and <italic>r</italic> = −0.47, <italic>p </italic><<italic> </italic>0.001, respectively). Chronic arterial hypertension was the only independent determinant of PVD<sub>small vessels</sub>.</p> </sec> <sec id="micc12219-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Preexistent chronic arterial hypertension was associated with lower vascular densities. In contrast, age showed no effect on sublingual microcirculation.</p> </sec> </abstract>