Physical Activity and Amyloid‐β Brain Levels in Elderly Adults with Intact Cognition and Mild Cognitive Impairment. Issue 8 (22nd July 2015)

• Record Type: Journal Article
• Authors: de Souto Barreto, Philipe; Andrieu, Sandrine; Payoux, Pierre; Demougeot, Laurent; Rolland, Yves; Vellas, Bruno; the Multidomain Alzheimer Preventive Trial/Data Sharing Alzheimer Study Group; Gillette‐Guyonnet, Sophie; Carrié, Isabelle; Brigitte, Lauréane; Faisant, Catherine; Lala, Françoise; Delrieu, Julien; Combrouze, Emeline; Badufle, Carole; Zueras, Audrey; Cantet, Christelle; Gardette, Virginie; Morin, Christophe; Kan, Gabor Abellan Van; Dupuy, Charlotte; Caillaud, Céline; Ousset, Pierre‐Jean; Willis, Sherry; Belleville, Sylvie; Gilbert, Brigitte; Fontaine, Francine; Dartigues, Jean‐François; Marcet, Isabelle; Delva, Fleur; Foubert, Alexandra; Cerda, Sandrine; Cuffi, Marie‐Noëlle; Costes, Corinne; Rouaud, Olivier; Manckoundia, Patrick; Quipourt, Valérie; Marilier, Sophie; Franon, Evelyne; Bories, Lawrence; Pader, Marie‐Laure; Basset, Marie‐France; Lapoujade, Bruno; Faure, Valérie; Tong, Michael Li Yung; Malick‐Loiseau, Christine; Cazaban‐Campistron, Evelyne; Desclaux, Françoise; Blatge, Colette; Dantoine, Thierry; Laubarie‐Mouret, Cécile; Saulnier, Isabelle; Clément, Jean‐Pierre; Picat, Marie‐Agnès; Bernard‐Bourzeix, Laurence; Willebois, Stéphanie; Désormais, Iléana; Cardinaud, Noëlle; Bonnefoy, Marc; Livet, Pierre; Rebaudet, Pascale; Gédéon, Claire; Burdet, Catherine; Terracol, Flavien; Pesce, Alain; Roth, Stéphanie; Chaillou, Sylvie; Louchart, Sandrine; Sudres, Kristelle; Lebrun, Nicolas; Barro‐Belaygues, Nadège; Touchon, Jacques; Bennys, Karim; Gabelle, Audrey; Romano, Aurélia; Touati, Lynda; Marelli, Cécilia; Pays, Cécile; Robert, Philippe; Duff, Franck Le; Gervais, Claire; Gonfrier, Sébastien; Gasnier, Yves; Bordes, Serge; Begorre, Danièle; Carpuat, Christian; Khales, Khaled; Lefebvre, Jean‐François; Idrissi, Samira Misbah El; Skolil, Pierre; Salles, Jean‐Pierre; Dufouil, Carole; Lehéricy, Stéphane; Chupin, Marie; Mangin, Jean‐François; Bouhayia, Ali; Allard, Michèle; Ricolfi, Frédéric; Dubois, Dominique; Martel, Marie Paule Bonceour; Cotton, François; Bonafé, Alain; Chanalet, Stéphane; Hugon, Françoise; Bonneville, Fabrice; Cognard, Christophe; Chollet, François; Voisin, Thierry; Peiffer, Sophie; Hitzel, Anne; Zanca, Michel; Monteil, Jacques; Darcourt, Jacques; Molinier, Laurent; Derumeaux, Hélène; Costa, Nadège; Vincent, Christian; Perret, Bertrand; Vinel, Claire; Savy, S; Coley, N;
• Is Part Of: Journal of the American Geriatrics Society. Volume 63:Issue 8(2015:Aug.)
• Page Start: 1634
• Page End: 1639
• Publication Date: 2015-07-22
• Subjects: Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.13530
• Languages: English
• ISSNs: 0002-8614

Abstract

<abstract abstract-type="main" id="jgs13530-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jgs13530-sec-0001" sec-type="section"> <title>Objectives</title> <p>To examine the associations between amyloid‐<italic>β</italic> brain deposition and physical activity (PA) in elderly adults without dementia and to investigate whether the association has a dose‐response relationship.</p> </sec> <sec id="jgs13530-sec-0002" sec-type="section"> <title>Design</title> <p>Cross‐sectional study.</p> </sec> <sec id="jgs13530-sec-0003" sec-type="section"> <title>Setting</title> <p>French community‐dwelling people.</p> </sec> <sec id="jgs13530-sec-0004" sec-type="section"> <title>Participants</title> <p>Elderly adults with normal or mildly impaired cognition (mean age 74.7 ± 4.2; 60.4% female) with available information on current self‐reported PA and amyloid‐<italic>β</italic> brain deposition measured using positron emission tomography (PET) using the PET‐ligand florbetapir F 18 (n = 268).</p> </sec> <sec id="jgs13530-sec-0005" sec-type="section"> <title>Measurements</title> <p>A standardized uptake value ratio (SUVR) was obtained for each subject. Participants were divided according to amyloid plaque cortical retention defined according to a SUVR cutoff of 1.10 (SUVR+ vs SUVR−).</p> </sec> <sec id="jgs13530-sec-0006" sec-type="section"> <title>Results</title> <p>Bivariate and multivariate analyses showed that PA was not significantly associated with SUVR. SUVR+ and SUVR− participants did not differ in terms of volume (continuous PA variables) and levels (categorical PA variables) of PA. PA was not correlated with SUVR in apolipoprotein E <italic>ε</italic>4 carriers or noncarriers. PA was not associated with cognitive function.</p> </sec> <sec id="jgs13530-sec-0007" sec-type="section"> <title>Conclusion</title> <p>Although PA protects against dementia, there is no solid evidence that this protection involves a reduction in amyloid‐<italic>β</italic> brain deposition. Further studies are needed to determine whether PA (ideally measured at several time‐points using objective measures) is involved in the pathophysiology of Alzheimer's disease.</p> </sec> </abstract>