Development and validation of a cost–utility model for Type 1 diabetes mellitus1. Issue 8 (13th February 2015)

• Record Type: Journal Article
• Authors: Wolowacz, S.; Pearson, I.; Shannon, P.; Chubb, B.; Gundgaard, J.; Davies, M.; Briggs, A.
• Is Part Of: Diabetic medicine. Volume 32:Issue 8(2015:Aug.)
• Page Start: 1023
• Page End: 1035
• Publication Date: 2015-02-13
• Subjects: Diabetes -- Periodicals; 616.462
• DOI: 10.1111/dme.12663
• Languages: English
• ISSNs: 0742-3071

Abstract

<abstract abstract-type="main" id="dme12663-abs-0001"> <title>Abstract</title> <sec id="dme12663-sec-0001" sec-type="section"> <title>Aims</title> <p>To develop a health economic model to evaluate the cost‐effectiveness of new interventions for Type 1 diabetes mellitus by their effects on long‐term complications (measured through mean HbA<sub>1c</sub>) while capturing the impact of treatment on hypoglycaemic events.</p> </sec> <sec id="dme12663-sec-0002" sec-type="section"> <title>Methods</title> <p>Through a systematic review, we identified complications associated with Type 1 diabetes mellitus and data describing the long‐term incidence of these complications. An individual patient simulation model was developed and included the following complications: cardiovascular disease, peripheral neuropathy, microalbuminuria, end‐stage renal disease, proliferative retinopathy, ketoacidosis, cataract, hypoglycemia and adverse birth outcomes. Risk equations were developed from published cumulative incidence data and hazard ratios for the effect of HbA<sub>1c</sub>, age and duration of diabetes. We validated the model by comparing model predictions with observed outcomes from studies used to build the model (internal validation) and from other published data (external validation). We performed illustrative analyses for typical patient cohorts and a hypothetical intervention.</p> </sec> <sec id="dme12663-sec-0003" sec-type="section"> <title>Results</title> <p>Model predictions were within 2% of expected values in the internal validation and within 8% of observed values in the external validation (percentages represent absolute differences in the cumulative incidence).</p> </sec> <sec id="dme12663-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The model utilized high‐quality, recent data specific to people with Type 1 diabetes mellitus. In the model validation, results deviated less than 8% from expected values.</p> </sec> </abstract>