Impact of DEFB1 gene regulatory polymorphisms on hBD-1 salivary concentration. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Polesello, Vania; Zupin, Luisa; Di Lenarda, Roberto; Biasotto, Matteo; Ottaviani, Giulia; Gobbo, Margherita; Cecco, Luca; Alberi, Giulia; Pozzato, Gabriele; Crovella, Sergio; Segat, Ludovica
• Is Part Of: Archives of oral biology. Volume 60:Issue 7(2015:Jul.)
• Page Start: 1054
• Page End: 1058
• Publication Date: 2015-07
• Subjects: Mouth -- Periodicals; Mouth -- Diseases -- Periodicals; Dentistry -- Periodicals; Electronic journals; 617.6005
• DOI: 10.1016/j.archoralbio.2015.03.009
• Languages: English
• ISSNs: 0003-9969

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005"> <italic>DEFB1</italic> 5′ untranslated region (UTR) polymorphisms were genotyped in Italian healthy subjects.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The salivary concentration of human β-defensin 1 (hDB-1) was measured in Italian healthy subjects.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015"> <italic>DEFB1</italic> genotypes were correlated with the hDB-1 salivary concentration.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">The −52 G/G and −44C/G genotype were associated with high protein levels.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025"> <italic>DEFB1 5′</italic>UTR genetic variants may influence the hDB-1 expression.</p> </list-item> </list> </p> </sec> </abstract>