Serum bactericidal antibody assays – The role of complement in infection and immunity. Issue 36 (26th August 2015)

• Record Type: Journal Article
• Authors: McIntosh, E.D.G.; Bröker, M.; Wassil, J.; Welsch, J.A.; Borrow, R.
• Is Part Of: Vaccine. Volume 33:Issue 36(2015)
• Page Start: 4414
• Page End: 4421
• Publication Date: 2015-08-26
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.07.019
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The accepted correlate of protection for meningococcal infection is the SBA assay.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Complement is key for protecting against meningococcal disease.</p> </list-item> <list-item id="lsti0016"> <label></label> <p id="par0011">Selecting complement lacking strain specific antibodies is criticial for SBA assay.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Complement for serogroups A, B, C, W, and Y assays is from humans or rabbits.</p> </list-item> <list-item id="lsti0017"> <label></label> <p id="par0019">rSBA is not used for serogroup B vaccine licensure due to anti-B PS IgM antibodies.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Meningococci have proteins, for example fHbp, that bind human but not other species.</p> </list-item> <list-item id="lsti0021"> <label></label> <p id="par0021">Complement lacking human fH measures higher titres: the bacteria are more susceptible.</p> </list-item> </list> </p> </sec> </abstract>