Adjuvant potential of resiquimod with inactivated Newcastle disease vaccine and its mechanism of action in chicken. Issue 36 (26th August 2015)

• Record Type: Journal Article
• Authors: Sachan, Swati; Ramakrishnan, Saravanan; Annamalai, Arunsaravanakumar; Sharma, Bal Krishan; Malik, Hina; Saravanan, B.C.; Jain, Lata; Saxena, Meeta; Kumar, Ajay; Krishnaswamy, Narayanan
• Is Part Of: Vaccine. Volume 33:Issue 36(2015)
• Page Start: 4526
• Page End: 4532
• Publication Date: 2015-08-26
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.07.016
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Resiquimod (R-848) showed potential adjuvant capacity with Newcastle disease (ND) vaccine in SPF chicken.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">R-848 enhanced antigen specific humoral as well as cellular immune responses.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">R-848 up-regulated the expression of IFN-α, IFN-β, IFN-γ, IL-4, IL-1β, MHC-II and iNOS transcripts in the chicken spleen.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">R-848 potentiated the protection capacity of inactivated ND vaccine against virulent ND virus challenge.</p> </list-item> </list> </p> </sec> </abstract>