Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice. Issue 36 (26th August 2015)

• Record Type: Journal Article
• Authors: Martinez-Campos, Viridiana; Martinez-Vega, Pedro; Ramirez-Sierra, Maria Jesus; Rosado-Vallado, Miguel; Seid, Christopher A.; Hudspeth, Elissa M.; Wei, Junfei; Liu, Zhuyun; Kwityn, Cliff; Hammond, Molly; Ortega-López, Jaime; Zhan, Bin; Hotez, Peter J.; Bottazzi, Maria Elena; Dumonteil, Eric
• Is Part Of: Vaccine. Volume 33:Issue 36(2015)
• Page Start: 4505
• Page End: 4512
• Publication Date: 2015-08-26
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.07.017
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">The Tc24 antigen from <italic>Trypanosoma cruzi</italic> is under evaluation as a vaccine candidate against Chagas disease.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">We developed a suitable platform for the large scale production of recombinant Tc24.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Immunization of mice with rTc24 with a monophosphoryl-lipid A induces a Th1-biased immune response.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Immunized mice were partially protected against an experimental infection.</p> </list-item> </list> </p> </sec> </abstract>