In vitro and in vivo growth alter the population dynamic and properties of a Jeryl Lynn mumps vaccine. Issue 36 (26th August 2015)

• Record Type: Journal Article
• Authors: Connaughton, Sarah M.; Wheeler, Jun X.; Vitková, Eva; Minor, Philip; Schepelmann, Silke
• Is Part Of: Vaccine. Volume 33:Issue 36(2015)
• Page Start: 4586
• Page End: 4593
• Publication Date: 2015-08-26
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.06.109
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Mumps vaccines contain live attenuated viruses that are manufactured in cell substrates.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The production of the JL-CK vaccine in primary canine kidney cells is atypical.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Genetic changes introduced by different cell types have not been investigated.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">JL-CK vaccine contains a unique mix of mumps viruses that have acquired a number of mutations.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Growth in cell or animal substrates dramatically alters the population dynamic of JL-CK.</p> </list-item> </list> </p> </sec> </abstract>