Differential changes in sphingolipids between TNF-induced necroptosis and apoptosis in U937 cells and necroptosis-resistant sublines. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Sawai, Hirofumi; Ogiso, Hideo; Okazaki, Toshiro
• Is Part Of: Leukemia research. Volume 39:Issue 9(2015:Sep.)
• Page Start: 964
• Page End: 970
• Publication Date: 2015-09
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.06.002
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Changes in sphingolipids in necroptosis were investigated using mass spectrometry.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The ceramide level in necroptosis was twice as high as that in apoptosis after 4 h.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">An increase in PI-positive cells was observed only in necroptosis within 4 h.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">BHA inhibited increases in ceramide levels in necroptosis but not in apoptosis.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">The ROS-induced large increase in ceramide levels may play a role in necroptosis.</p> </list-item> </list> </p> </sec> </abstract>