The novel biomarker of alternative macrophage activation, soluble mannose receptor (sMR/sCD206): Implications in multiple myeloma. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Andersen, Morten N.; Andersen, Niels F.; Rødgaard-Hansen, Sidsel; Hokland, Marianne; Abildgaard, Niels; Møller, Holger J.
• Is Part Of: Leukemia research. Volume 39:Issue 9(2015:Sep.)
• Page Start: 971
• Page End: 975
• Publication Date: 2015-09
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.06.003
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Mannose receptor (MR/CD206) is highly expressed on tumor-associated macrophages.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">We recently discovered the existence of a soluble form of MR (sMR) in human serum.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Here we report the first data on sMR levels in patients with malignant disease.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Increased sMR at diagnosis is a marker of poor prognosis in multiple myeloma.</p> </list-item> </list> </p> </sec> </abstract>