Mechanism of the inhibition of leukemia cell growth and induction of apoptosis through the activation of ATR and PTEN by the topoisomerase inhibitor 3EZ, 20Ac-ingenol. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Miyata, Shohei; Fukuda, Yasuaki; Tojima, Haruka; Matsuzaki, Keiichi; Kitanaka, Susumu; Sawada, Hiroshi
• Is Part Of: Leukemia research. Volume 39:Issue 9(2015:Sep.)
• Page Start: 927
• Page End: 932
• Publication Date: 2015-09
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.06.006
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">3EZ, 20Ac-ingenol showed characteristics as a topoisomerase catalytic inhibitor, inducing DNA damage.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The alteration of the chromatin structure by the compound induced ATM/AKT and PTEN pathway.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The stabilized p53 by modulating two signaling pathway induced apoptosis via the activation of Bcl-2 family genes.</p> </list-item> </list> </p> </sec> </abstract>